Statistical Summary of 2P2IDB 2.0 Interfaces (02/2016)

The table below shows "means" and "standard deviations" of interfaces parameters calculated for the three classes of druggable complexes in 2P2IDB.

 

Interface Properties 2P2IDB
Class 1
(Protein/Peptide)
Class 2
(Protein/Protein)
Class BRD
(Bromodomain/Histone)
Nb of complexes 10 10 7
BASA (Å2) 1284.4 ±251.6 2011.9 ±801.6 1252.1 ±186.8
% Polar BASA 53.3 ±18.7 73.3 ±16.1 58.5 ±7.9
Gap Volume (Å3) 2143.1 ±1460.4 5510.0 ±3290.0 1499.0 ±389.6
Non-bonded contacts 74.3 ±24.9 113.1 ±46.3 72.4 ±14.1
Total Nb of segments 4.4 ±1.5 8.8 ±2.8 3.7 ±0.4
Nb of hydrogen bonds 2.5 ±1.2 4.7 ±2.8 2.9 ±1.6
Nb of salt bridges 0.4 ±1.2 0.2 ±0.6 0.0 ±0.0


2P2Idb v2: Update of a Structural Database Dedicated to Orthosteric Modulation of Protein-Protein Interactions Basse MJ, Betzi S, Morelli X, Roche P. Database update 2016. DOI : 10.1093/database/baw007

2P2Idb: A Structural Database Dedicated to Orthosteric Modulation of Protein-Protein Interactions Basse MJ, Betzi S, Bourgeas R, Bouzidi S, Chetrit B, Hamon V, Morelli X, Roche P. Nucleic Acid Research 2013; 41:D824-827. Pubmed ID: 23203891