2P2IDB is a hand-curated database dedicated to the structure of protein-protein complexes with known small molecule inhibitors. We have gathered from the PDB, 26 PPIs and 242 small molecule inhibitors found at the interface (Basse et al., 2016; Basse et al., 2013; Bourgeas et al., 2010). Interfaces in 2P2IDB have been analyzed in terms of geometrical parameters, atom and residue properties, buried accessible surface area and other biophysical parameters and compared to those of representative datasets of heterodimeric complexes. The 26 complexes have been classified into 3 classes based on the number of segments at the interface and target properties. Class 1 corresponds to protein-peptide complexes, Class 2 corresponds to globular protein-protein complexes and Class 3 corresponds to Bromodomain/Histone protein-protein complexes.
This web server allows the user to browse the 2P2I database, to retrieve precalculated structural information of PPI interfaces and to view interactively protein-protein and protein-ligand complexes through JSmol applets.
The latest version (23-05-2018) contains 32 Protein-Protein complexes, 672 Protein-Ligand complexes and 600 PPI inhibitors.
The database is maintained by Marie-Jeanne Basse
2P2Idb v2: Update of a Structural Database Dedicated to Orthosteric Modulation of Protein-Protein Interactions Basse MJ, Betzi S, Morelli X, Roche P. Database update 2016. DOI : 10.1093/database/baw007
2P2Idb: A Structural Database Dedicated to Orthosteric Modulation of Protein-Protein Interactions Basse MJ, Betzi S, Bourgeas R, Bouzidi S, Chetrit B, Hamon V, Morelli X, Roche P. Nucleic Acid Research 2013;41:D824-827. Pubmed ID: 23203891