2P2IDB is a hand-curated database dedicated to the structure of protein-protein complexes with known small molecule inhibitors. In the 2016 version of the database, we have gathered from the PDB, 26 PPIs and 242 small molecule inhibitors found at the interface (Basse et al., 2016).
Interfaces in 2P2IDB have been analyzed in terms of geometrical parameters, atom and residue properties, buried accessible surface area and other biophysical parameters and compared to those of representative datasets of heterodimeric complexes.
The 26 complexes have been classified into 3 classes based on the number of segments at the interface and target properties. Class 1 corresponds to protein-peptide complexes, Class 2 corresponds to globular protein-protein complexes and Class 3 corresponds to Bromodomain/Histone protein-protein complexes.
Since 2016, 2P2IDB is updated monthy.
The latest version (03-07-2019) contains 32 Protein-Protein complexes, 890 Protein-Ligand complexes and 796 PPI inhibitors.
The database is maintained by Marie-Jeanne Basse
2P2Idb v2: Update of a Structural Database Dedicated to Orthosteric Modulation of Protein-Protein Interactions Basse MJ, Betzi S, Morelli X, Roche P. Database update 2016. DOI : 10.1093/database/baw007
2P2Idb: A Structural Database Dedicated to Orthosteric Modulation of Protein-Protein Interactions Basse MJ, Betzi S, Bourgeas R, Bouzidi S, Chetrit B, Hamon V, Morelli X, Roche P. Nucleic Acid Research 2013;41:D824-827. Pubmed ID: 23203891